: Go to Settings > Privacy & security > Windows Security > Device security .
If disabling security doesn't work, the driver files may be corrupted. Open (Win + X). Expand Universal Serial Bus controllers . mastercam+x72022+virtual+usb+bus+error+39+fixed
Fixing the typically requires disabling the Windows Core Isolation (Memory Integrity) security feature, which often blocks the specialized drivers used for HASP keys or virtual USB emulators. Direct Solutions for Error 39 1. Disable Core Isolation (Recommended) : Go to Settings > Privacy & security
Navigate to: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Class\{36fc9e60-c465-11cf-8056-444553540000} (This is the class for USB controllers). mastercam+x72022+virtual+usb+bus+error+39+fixed
Check the box for .
This is the most frequent fix for modern Windows 10 and 11 systems where security features prevent the Virtual USB Bus driver from loading.