Most iProg software versions are hardcoded to work with a specific serial (e.g., SN1, SN35, SN45). If your hardware SN doesn't match what the software expects, it will refuse to "link."
If your antivirus has deleted the .exe or a .dll file, the program might open but will be unable to "link" to the hardware. iprog programmer not connected link
Are you using an or a clone , and which firmware version is currently displayed in your software? Most iProg software versions are hardcoded to work