While "runes" are not an in-game item (the game uses "sigils"), the term "RUNE" in your keyword typically refers to a that packages game updates for PC.
Allows you to combine specific traits (e.g., War Elemental + Damage Cap) into one slot. Transmute 100+ Sigils at once
: The "RUNE better" sentiment often stems from these releases including all DLC and bug fixes (like the intermittent stat scaling bugs) in a single, stable package.
The official v1.1.x updates transformed the endgame by introducing high-stakes boss battles and more granular control over character builds.